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TDB-HS15 VacciGrade™
Synthetic cord factor analog
Trehalose-6,6-dibehenate formulated with Kolliphor® HS 15
Trehalose-6,6-dibehenate (TDB) is a non-toxic synthetic analogue of TDM and an effective adjuvant for Th1/Th17 vaccination.
TDB was found to rely on Mincle, Syk and Card9 for its adjuvant activity [1]. TDB is a poorly soluble compound and thus was formulated with Kolliphor® HS 15, a potent low-toxicity non-ionic solubilizer, to generate TDB-HS15, which is particularly suitable for in vivo studies. TDB-HS15 is a strong activator of NF-kB in a Mincle-dependent manner.
TDB-HS15 is available in a standard grade and VacciGrade™.
TDB VacciGrade™ is suitable for preclinical studies. It is prepared under strict aseptic conditions. It is guaranteed sterile and thoroughly tested for the presence of endotoxins.
TDB VacciGrade™ is for research use only, not for use in humans.
Specificity: Mincle agonist - Th1 response
Endotoxin level: < 5 EU/mg |