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TDB-HS15
Synthetic cord factor analog
Trehalose-6,6-dibehenate formulated with Kolliphor® HS 15
Trehalose-6,6-dibehenate (TDB) is a non-toxic synthetic analogue of trehalose-6,6-dimycolate (TDM, also known as cord factor), which is the most studied immunostimulatory component of Mycobacterium tuberculosis.
TDB is an effective adjuvant for Th1/Th17 vaccination. TDB was found to rely on Mincle, Syk and Card9 for its adjuvant activity [1]. TDB is a poorly soluble compound and thus was formulated with Kolliphor® HS 15, a potent low-toxicity non-ionic solubilizer, to generate TDB-HS15, which is particularly suitable for in vivo studies.
TDB-HS15 is a strong activator of NF-kB in a Mincle-dependent manner. TDB-HS15 is available in a standard grade and VacciGrade™.
Kolliphor® HS 15 (former tradename Solutol® HS 15) is a registered trademark of BASF.
Specificity: Mincle agonist
CAS number: 66758-35-8
Formula: C56H106O13
Molecular weight: 987.43
Working concentration: 0.3 - 100 µg/ml |