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TLR8 Native Genes
Toll-Like Receptor 8 native genes in expression plasmid
Alias: CD288, TLR08
TLR8 was identified together with TLR7 and TLR9 and is expressed more abundantly in PBL and lung [1].
The natural ligand for TLR8 is still unknown. Human TLR8 and TLR7 were reported to independently confer responsiveness to R848, an imidazoquinoline compound with antiviral activity. Upon R848 stimulation, HEK293 cells transfected with human TLR8 induced NF-κB activation in a dose-dependent manner [2].
In contrast, HEK293 cells expressing murine TLR8 were hyporesponsive to R848 suggesting that TLR8 is nonfunctional in mice.
This gene is available in pUNO1 expression plasmid selectable with Blasticidin or in pUNO3 expression plasmid selectable with Hygromycin or in pUNO1 expression plasmid selectable with Blasticidin.
Bovine TLR8 Native Genes (pUNO1-bTLR08)
Genbank: EF076722.1
ORF Size: 3102 bp
Subclone: BspHI - NheI
Human TLR8 (pUNO1-hTLR08)
Genbank: NM_138636
ORF Size: 3126 bp
Subclone: AgeI - NheI
Human TLR8 (pUNO3-hTLR08)
Genbank: NM_138636
ORF Size: 3126 bp
Subclone: AgeI - NheI
Mouse TLR8 (pUNO1-mTLR08)
Genbank: NM_133212.2
ORF Size: 3099 bp
Subclone: AgeI - NheI
Pig TLR8 Native Genes (pUNO1-pTLR08)
ORF Size: 3087 bp
Subclone: BspHI - NheI
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