|
TLR4 Native Genes
Toll-Like Receptor 4 native genes in expression plasmid
Alias: CD284, TLR4
TLR4, the first human TLR identified, is the receptor for Gram-negative lipopolysaccharide (LPS).
The TLR4 gene was shown to be mutated in C3H/HeJ and C57BL/10ScCr mice, both of which are low responders to lipopolysaccharide (LPS) [1]. However, TLR4 alone is not sufficient to confer LPS responsiveness. TLR4 requires MD-2, a secreted molecule, to functionally interact with LPS [2]. Furthermore, a third protein, called CD14, was shown to participate in LPS signaling, leading to NF-κB translocation. This signaling is mediated through the adapter protein MyD88 but also through a MyD88-independent pathway that involves the (TIR) domain-containing adapter protein (TIRAP) [3].
This gene is available in pUNO1 expression plasmid selectable with Blasticidin or in pUNO3 expression plasmid selectable with Hygromycin or in pUNO1 expression plasmid selectable with Blasticidin.
Bovine TLR4 Native Genes (pUNO1-bTLR04)
Genbank: NM_174198.6
ORF Size: 2526 bp
Subclone: AgeI - NheI
Human TLR4 isoform 1 (pUNO1-hTLR04a)
ORF Size: 2520 bp
Subclone: BspHI - NheI
Human TLR4 isoform 1 (pUNO3-hTLR04a)
ORF Size: 2520 bp
Subclone: BspHI - NheI
Mouse TLR4 (pUNO1-mTLR04)
Genbank: JX878358.1
ORF Size: 2508 bp
Subclone: BspHI - NheI
Pig TLR4 (pUNO1-pTLR04)
ORF Size: 2526 bp
Subclone: AgeI - NheI
|