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AhR Agonist V, VAF347
产品编号: |
182690-10MG
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产品名称:
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AhR Agonist V, VAF347 .0 订购此产品 |
供应商:
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Merck |
规格: |
*** |
目录价: |
1,837.00 |
库存状态: |
3周到货 |
CAS编号:
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应用范围: |
生化实验 |
种属来源: |
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相关信息: |
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AhR Agonist V, VAF347
(4-(3-Chloro-phenyl)-pyrimidin-2-yl)-(4-trifluoromethyl-phenyl)-amine
A cell-permeable pyrimidinylphenylamine compound that directly and reversibly targets aryl hydrocarbon receptor (AhR) with high-affinity, and induces AhR signaling. Reported to act as an immunomodulator with anti-inflammatory properties. Potently suppresses IgE secretion in B-cells with an IC50 of ~2 nM, and inhibits dendritic cells-mediated T-cell proliferation and cytokine production. Further, decreases lung eosinophilia in B-cell-deficient mice, and allergic inflammation. Downregulates PU.1 transcription factor, and impairs human monocytes and Langerhans dendritic cells differentiation.
产品信息
Form White solid
Molar mass 349.7
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥99% by HPLC
Solubility DMSO
Chemical formula C17H11ClF3N3
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Standard Handling |
保存条件: |
2°C - 8°C |
说明书地址: |
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