Autotaxin Inhibitor III, PF-8380 6-(3-(Piperazin-1-yl)propanoyl)-benzo[d]oxazol-2(3H)-one, Atx Inhibitor III, PF-8380 An orally bioavailable piperazinylbenzoxazolone compound that acts as a substrate competitive and tight-binding inhibitor of autotaxin activity {IC50 = 2.8 and 1.7 nM for recombinant human enzyme-β isoform employing FS-3 and LPC (lysophosphatidylcholine) as substrates, respectively; 1.16 and 1.15 nM for rat/murine enzyme-FS-3 and fetal fibroblast cell-LPC; 101 nM for human whole blood}. Displays desirable pharmacokinetics properties and efficiently blocks inflammation-induced LPA (lysophosphatidic acid) production both in plasma and at the site of inflammation by 95% in rat adjuvant-induced arthritis model (30 mg/kg, p.o.). 产品信息 Form Tan powder Molar mass 478.3 Protect from Light 是的 Packaged under inert gas 是的 Purity ≥95% by HPLC Solubility DMSO Chemical formula C22H21Cl2N3O5 CAS number 1144035-53-9 商店和运输信息 Storage -20°C Ship Dry Ice Only Standard Handling