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NBD-Binding Peptide II, Cell Permeable, CTP-NBD
产品编号: |
480026-5MG
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产品名称:
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NBD-Binding Peptide II, Cell Permeable, CTP-NBD .0 订购此产品 |
供应商:
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Merck |
规格: |
*** |
目录价: |
2,855.00 |
库存状态: |
3周到货 |
CAS编号:
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应用范围: |
生化实验 |
种属来源: |
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相关信息: |
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NBD-Binding Peptide II, Cell Permeable, CTP-NBD
NEMO-Binding Domain Binding Peptide II, Cell-Permeable, CTP-NBD
A cell-permeable cytoplasmic transduction peptide (CTP; YGRRARRRARR) fused to the NEMO binding domain peptide (NBD; TALDWSWLQTE) that acts as a potent inhibitor of TNFα-stimulated NF-κB activity (IC50 ~ 50 µM in HCT116 cells). Acts by interfering with the formation of active IKK complex and thereby prevents IκBα phosphorylation and its subsequent proteasomal degradation. Also blocks LPS-mediated increase in inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) activities. Colon-targeted capsules containing CTP-NBD are shown to reduce 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in rodent models (4.5 mg/kg/,p.o.) in vivo and diminish activities of myeloperoxidase and several inflammatory mediators. Antennapedia fused NBD cell-permeable peptide is also available (Cat. No. 480025).
产品信息
Peptide Sequence Ac-YGRRARRRARRTALDWSWLQTE-NH2
Form White solid
Formulation Supplied as a trifluoroacetate salt.
Primary Target NEMO-binding peptide
Molar mass 2846.2
Protect from Light 是的
Hygrocopic 是的
Packaged under inert gas 是的
Cell permeable 是的
Reversible 是的
Purity ≥97% by HPLC
Sold on the basis of peptide content 是的
Solubility H2O
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Standard Handling |
保存条件: |
2°C - 8°C |
说明书地址: |
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