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NBD-Binding Peptide II, Cell Permeable, CTP-NBD

产品编号: 480026-5MG     查看说明书
产品名称: NBD-Binding Peptide II, Cell Permeable, CTP-NBD  .0   订购此产品 
供应商: Merck
规格: ***
目录价: 2,855.00
库存状态: 3周到货
CAS编号:
应用范围: 生化实验
种属来源:
相关信息:

NBD-Binding Peptide II, Cell Permeable, CTP-NBD
NEMO-Binding Domain Binding Peptide II, Cell-Permeable, CTP-NBD
A cell-permeable cytoplasmic transduction peptide (CTP; YGRRARRRARR) fused to the NEMO binding domain peptide (NBD; TALDWSWLQTE) that acts as a potent inhibitor of TNFα-stimulated NF-κB activity (IC50 ~ 50 µM in HCT116 cells). Acts by interfering with the formation of active IKK complex and thereby prevents IκBα phosphorylation and its subsequent proteasomal degradation. Also blocks LPS-mediated increase in inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) activities. Colon-targeted capsules containing CTP-NBD are shown to reduce 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in rodent models (4.5 mg/kg/,p.o.) in vivo and diminish activities of myeloperoxidase and several inflammatory mediators. Antennapedia fused NBD cell-permeable peptide is also available (Cat. No. 480025).
产品信息
Peptide Sequence  Ac-YGRRARRRARRTALDWSWLQTE-NH2
Form  White solid
Formulation  Supplied as a trifluoroacetate salt.
Primary Target  NEMO-binding peptide
Molar mass  2846.2
Protect from Light  是的
Hygrocopic  是的
Packaged under inert gas  是的
Cell permeable  是的
Reversible  是的
Purity  ≥97% by HPLC
Sold on the basis of peptide content  是的
Solubility  H2O
商店和运输信息
Storage  +2°C to +8°C
Ship  Ambient Temperature Only
Standard Handling

保存条件: 2°C - 8°C
说明书地址: 点击查看详细
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