Cytoplasmic Dynein Inhibitor, Ciliobrevin D

Cytoplasmic Dynein Inhibitor, Ciliobrevin D
2-(7-chloro-4-oxo-3,4-dihydroquinazolin-2(1H)-ylidene)-3-(2,4-dichlorophenyl)-3-oxopropanenitrile, AAA+ ATPase motor cytoplasmic dynein inhibitor
A cell-permeable benzoyl dihydroquinazolinone derivative that acts as a reversible and specific blocker of AAA+ ATPase motor cytoplasmic dynein and disrupts spindle pole focusing, cold-stable microtubule formation, kinetochore-microtubule attachment, and melanosome aggregation in a dose-dependent manner (~10 to 40 µM). Shown to perturb protein trafficking within the primary cilia and cause a significant increase in intraflagellar transport protein 88 (IFT88) levels at the distal tip of primary cilia. Reported to disrupt primary cilium-dependent Gli regulation and block Hedgehog signaling.
产品信息
Form  Orange powder
Molar mass  392.6
Protect from Light  是的
Packaged under inert gas  是的
Purity  ≥99% by HPLC
Solubility  DMSO
Chemical formula  C17H8Cl3N3O2
商店和运输信息
Storage  -20°C
Ship  Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Standard Handling