CRM1 Inhibitor III (Z)-But-2-enedioic acid (4′-bromophenyl)amide (3′′-chlorophenyl)amide, Chromosome Region Maintenance 1 Protein Inhibitor III, Exportin 1 Inhibitor III, XPO1 Inhibitor III A cell-permeable butenediamide compound that acts as a potent, active site cysteine reactive irreversible inhibitor of CRM1/exportin 1. Shown to selectively repress agonist-mediated nuclear export of HDAC4/5, Rev and NFAT proteins in neonatal rat ventricular myocytes (NRVMs; EC50 = 2.2 and 3.5 nM for GFP-HDAC5 and GFP-HIV Rev) and suppress hypertrophic growth of NRVMs (EC50 = 52 nM for ANF expression inhibition) with negligible effect either on the phosphorylation of HDAC5 or on the kinase activities of PKD and CaMKII at 1 µM. 产品信息 Form Yellow powder Molar mass 379.6 Protect from Light 是的 Packaged under inert gas 是的 Purity ≥95% by HPLC Solubility DMSO Chemical formula C16H12BrClN2O2 商店和运输信息 Storage +2°C to +8°C Ship Shipped at Ambient Temperature or with Blue Ice or with Dry Ice Standard Handling