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CAY10502Exclusive
Cayman Chemical Item Number 10008657
Description
Phospholipase A2 (PLA2) catalyzes the hydrolysis of phospholipids at the sn-2 position leading to the production of lysophospholipids and free fatty acids. Calcium-dependent cytosolic PLA2 (cPLA2α) is a 85 kDa enzyme that plays a key role in the arachidonic cascade and the inflammatory response associated with this metabolic pathway.1↗ CAY10502 is a potent inhibitor of cPLA2α with an IC50 value of 4.3 nM for the purified enzyme from human platelets.2↗ It inhibits arachidonic acid mobilization from A23187-stimulated or TPA-stimulated human platelets with IC50 values of 570 and 0.9 nM, respectively.2↗
Formal Name 1-[3-[4-(decyloxy)phenoxy]-2-oxopropyl]-1H-indole-3,5-dicarboxylic acid, 3-methyl ester
CAS Number 888320-29-4
Molecular Formula C30H37NO7
Formula Weight 523.6
Formulation A crystalline solid
Purity ≥98%
λmax 236, 289 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES O=C(COC1=CC=C(OCCCCCCCCCC)C=C1)CN2C3=CC=C(C(O)=O)C=C3C(C(OC)=O)=C2
InCHI Code 1S/C30H37NO7/c1-3-4-5-6-7-8-9-10-17-37-24-12-14-25(15-13-24)38-21-23(32)19-31-20-27(30(35)36-2)26-18-22(29(33)34)11-16-28(26)31/h11-16,18,20H,3-10,17,19,21H2,1-2H3,(H,33,34)
InCHI Key NXDZVUAKVFVDSL-UHFFFAOYSA-N |