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CAY10505
Cayman Chemical Item Number 10009078
Description Phosphoinositide 3-kinase γ (PI3Kγ), expressed primarily in hematopoietic cells, plays several important roles in immunity. CAY10505 is a potent inhibitor of PI3K, selectively inhibiting the γ isoform (IC50 = 30 nM) better than the α, β, and δ isoforms (IC50 = 0.94, 20, and 20 μM, respectively).1↗ Tested against a panel of 80 other kinases, CAY10505 significantly inhibits only the unrelated casein kinase 2 (CK2, IC50 = 20 nM). It also inhibits the phosphorylation of the PI3K substrate PKB/Akt in mouse macrophages (IC50 = 228 nM).1↗ Oral administration of CAY10505 reduces neutrophil recruitment in mice to an extent that is comparable to that observed in PI3Kγ-deficient mice.1↗
Formal Name 5-[[5-(4-fluorophenyl)-2-furanyl]methylene]-2,4-thiazolidinedione
CAS Number 328960-84-5
Molecular Formula C14H8FNO3S
Formula Weight 289.3
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES Fc1ccc(cc1)c1ccc(/C=C2\SC(=O)NC/2=O)o1
InCHI Code 1S/C14H8FNO3S/c15-9-3-1-8(2-4-9)11-6-5-10(19-11)7-12-13(17)16-14(18)20-12/h1-7H,(H,16,17,18)/b12-7+
InCHI Key UFBTYTGRUBUUIL-KPKJPENVSA-N |