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CAY10499Exclusive
Cayman Chemical Item Number 10007875
Description Hormone sensitive lipase (HSL) catalyzes the hydrolysis of tri-, di-, and monoacylglycerols, as well as cholesterol esters, thus mobilizing fatty acids as a primary source of energy in mammals.1↗ The enzyme is highly expressed in adipose tissue and steroidogenic tissues, and less abundantly in skeletal muscle, heart, brain, pancreatic beta cells, adrenal gland, ovaries, testes, and macrophages. Its presence in various tissues indicates the enzyme plays diverse roles including those in steroidogenesis and spermatogenesis, foam cell formation in atherosclerosis, and diabetes.1↗,2↗ CAY10499 is a potent inhibitor of human HSL exhibiting an IC50 of 90 nM for the recombinant enzyme.3↗ The in vivo pharmacological efficacy of CAY10499 has not been reported.
Formal Name [4-(5-methoxy-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-2-methylphenyl]-carbamic acid, phenylmethyl ester
CAS Number 359714-55-9
Molecular Formula C18H17N3O5
Formula Weight 355.3
Formulation A crystalline solid
Purity ≥98%
λmax 206, 256 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES COc1nn(c2ccc(NC(=O)OCc3ccccc3)c(C)c2)c(=O)o1
InCHI Code 1S/C18H17N3O5/c1-12-10-14(21-18(23)26-17(20-21)24-2)8-9-15(12)19-16(22)25-11-13-6-4-3-5-7-13/h3-10H,11H2,1-2H3,(H,19,22)
InCHI Key QTENHWTVRQKWRI-UHFFFAOYSA-N |