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Zymosan
Cell wall preparation of S. cerevisiae
Zymosan, an insoluble preparation of cell wall from Saccharomyces cerevisiae, activates macrophages via TLR2. TLR2 cooperates with TLR6 and CD14 in response to zymosan [1]. Zymosan is also recognized by Dectin-1, a phagocytic receptor expressed on macrophages and dendritic cells, which collaborates with TLR2 and TLR6 enhancing the immune responses triggered by the recognition of Zymosan by each receptor [2].
Specificity: TLR2 and Dectin-1 agonist
Working concentration: 1 - 10 μg/ml
Endotoxin level: EndoFit™ (<0.001 EU/μg)
Solubility: Insoluble (resuspended zymosan results in a cloudy suspension) |