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Z-VAD-FMK
NLRP3 Inflammasome Inhibitor - Caspase inhibitor
Z-VAD-FMK is a cell-permeable pan-caspase inhibitor that irreversibly binds to the catalytic site of caspase proteases [1].
The peptide is O-methylated in the P1 position on aspartic acid, providing enhanced stability and increased cell permeability.
Z-VAD-FMK is used in apoptosis studies and also in inflammasome studies. It is a potent inhibitor of caspase-1 activation in NLRP3-induced cells [2].
Moreover, through the inhibition of caspases 3, 7 and 8, Beclin1 is stabilized and autophagy is promoted by Z-VAD-FMK.
Working concentration: 10 μg/ml (20 μM)
Purity: 95%
Molecular weight: 467.5
Solubility: Soluble in DMSO (20 mM/10 mg/ml) |