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U0126
MAP Kinase Inhibitor - Autophagy Inhibitor - MEK1 and MEK2 Inhibitor
U0126 is a selective inhibitor of MAP kinase kinases, MEK1 and MEK2 [1].
It acts by inhibiting the kinase activity of MEK1/2 thus preventing the activation of MAP kinases p42 and p44 which are encoded by the erk2 and erk1 genes respectively. MAPK p42/p44 are involved in the signaling cascade triggered by LPS and other ligands through stimulation of the TLRs [2,3,4].
U0126 inhibits MEK1 and MEK2, and thus ERK activation. U0126 can be used to study the role of ERK, a MAPK involved in the induction of autophagy.
Working concentration: 10- 50 µM
CAS number: 109511-58-2
Synonym: 1,4-Diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)-butadiene
Molecular weight: 380.5
Solubility: DMSO, 10 mg/ml
Purity: >99% (HPLC, TLC) |