Tamoxifen Estrogen receptor antagonist - Autophagy inducer Tamoxifen is an antagonist of the estrogen receptor known to induce autophagy. Tamoxifen stimulates autophagy by increasing the intracellular level of ceramide, which inhibits mTOR activation and/or stimulates expression of Atg genes. Working Concentration: 10 - 100 µM CAS number: 54965-24-1 Formula: C32H37NO8 Molecular weight: 563.64 Solubility: Water 0.3 mg/L at 20°C. 0.2 mg/ml in 0.02 N HCl at 37°C. Soluble in methanol at 50 mg/ml (some heat may be needed) and in ethanol at 10 mg/ml with sonication. A 4.0 mM solution in DMSO can be prepared. Purity: >99%