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VEGFR2/Flt3/c-Kit Inhibitor
N-(4-(3-Amino-1H-indazol-4-yl)phenyl)-N′-(3-methylphenyl)urea, Vascular Endothelial Growth Factor Receptor-2/Flt3/c-Kit Inhibitor, c-Kit Inhibitor I, Flt-3 Inhibitor V, VEGFR Tyrosine Kinase Inhibitor XXV, VEGFR2 Kinase Inhibitor XXII
A cell-permeable 3-aminoindazolylurea compound that acts as a potent and ATP-competitive inhibitor of VEGFR2/KDR (IC50 = 3 nM) as well as Flt3 and cKit (IC50 = 4 to 20 nM). Shown to block VEGF-induced VEGFR2 phosphorylation in 3T3-murine fibroblasts in vitro (IC50 = 13 nM) and exhibit oral availability (AUC = 6.5 µM•h with an oral dose of 10 mg/kg in CD-1 mice) and in vivo efficacy in a murine estradiol-induced uterine edema model (ED50 = 4 mg/kg p.o. in balb/c mice).
产品信息
Form Off-white solid
Molar mass 357.4
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥97% by HPLC
Solubility DMSO or EtOH
Chemical formula C21H19N5O
CAS number 796967-10-7
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Standard Handling |