|
VEGFR Tyrosine Kinase Inhibitor V
N-Cyclopropyl-6-(6,7-dimethoxyquinolin-4-yloxy)-1-naphthamide, HCl, VEGF Receptor Tyrosine Kinase Inhibitor V, VEGFR2 Kinase Inhibitor XXIII, VEGFR1 Kinase Inhibitor VI, VEGFR3 Kinase Inhibitor VI
A cell-permeable, ATP-binding pocket-targeting N-cyclopropylnaphthamide compound that acts as a potent inhibitor against VEGFR1/2/3 (IC50 = 0.6 nM against VEGFR2), c-FMS, RET, Lyn, and c-KIt, while exhibiting much reduced activity against 36 other commonly studied kinases. Selectively inhibits HUVEC proliferation induced by VEGF over bFGF (IC50 = 0.91 vs. 170 nM, respectively). It is orally active in mice and rats and is shown to effectively reduce VEGF-mediated vascular permeability and angiogenesis in vivo.
产品信息
Form Beige solid
Molar mass 468.9
Protect from Light 是的
Hygrocopic 是的
Packaged under inert gas 是的
Purity ≥97% by HPLC
Solubility DMSO or EtOH
Chemical formula C25H22N2O4 • HCl • H2O
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Standard Handling |