VEGF Inhibitor, CBO-P11 A macrocyclic 17-amino acid peptide derived from residues 79 - 93 of vascular endothelial growth factor that mediate its binding to VEGFR-2. It blocks the binding of VEGF165 to its receptors (IC50 = 700 nM for VEGFR1, 1.3 µM for VEGFR2) and exhibits anti-angiogenic activity as well as other VEGFR-mediated cellular functions, such as proliferation (IC50 = 5.8 µM), migration (IC50 = 8.2 µM), and activation of MAP kinases. Its anti-angiogenic activity has been successfully demonstrated in vivo using chick embryos and nude mice tumor models of human intracranial and syngeneic glioma. 产品信息 Peptide Sequence cyclic(D-Phe-Pro-Gln-Ile-Met-Arg-Ile-Lys-Pro-His-Gln-Gly-Gln-His-Ile-Gly-Glu) Form White lyophilized solid Formulation Supplied as a trifluoroacetate salt. Molar mass 1998.3 Protect from Light 是的 Hygrocopic 是的 Packaged under inert gas 是的 Purity ≥97% by HPLC Solubility DMSO or H2O Chemical formula C90H140N28O22S 商店和运输信息 Storage -20°C Ship Shipped with Blue Ice or with Dry Ice Carcinogenic / Teratogenic