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AG 538
α-Cyano-(3,4-dihydroxy)cinnamoyl-(3′,4′-dihydroxyphenyl)ketone, Tyrphostin AG 538
A potent, cell-premeable, reversible, and competitive inhibitor of IGF-1 receptor kinase (IC50 = 400 nM). Reaction is competitive with respect to IGF-1R substrate. Also inhibits the phosphorylation of PTK substrate poly(Glu,Tyr) by IGF-1R, IR, EGF-R, and Src (IC50 = 60 nM, 113 nM, 370 nM, and 2.4 µM, respectively). Inhibits the phosphorylation of PKB at a much higher concentration (IC50 = 76 µM).
产品信息
Form Dark yellow solid
Primary Target IGF-1 receptor kinase
Primary Target IC50 400 nM
Secondary target phosphorylation of PTK substrate poly(Glu,Tyr) by IGF-1R, IR, EGR-R, and Src (IC50 = 60 nM, 113 nM, 370 nM, and 2.4 mM, respectively), inhibits the phosphorylation of PKB at a much higher concentration (IC50 = 76 mM)
Molar mass 297.3
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥95% by HPLC
Solubility DMSO
Chemical formula C16H1NO5
CAS number 133550-18-2
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Standard Handling |