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AG 490, m-CF3
NSC D722757, α-Cyano-(3,4-dihydroxy)-N-(m-trifluoromethyl)benzylcinnamide, 5H4
A cell-permeable, reversible, substrate competitive, m-trifluoromethyl derivative of AG 490 (Cat. No. 658401) that displays apoptotic and antiproliferative properties (IC50 = 1.7 µM, 2.8 µM and 6.1 µM in 2E8, Baf/3 and Jurkat cells, respectively). Shown to inhibit IL-7-induced JAK3 tyrosine phosphorylation in 2E8 cells in vitro and significantly reduce lymph node cellularity in a murine B and T cell lymphoma model (1 mg per animal, i.p.) in vivo.
产品信息
Form Yellow solid
Primary Target apoptotic and antiproliferative properties
Primary Target IC50 1.7 µM, 2.8 µM and 6.1 µM in 2E8, Baf/3 and Jurkat cells, respectively
Secondary target IL-7-induced JAK3 tyrosine phosphorylation in 2E8 cells in vitro
Molar mass 362.3
Protect from Light 是的
Packaged under inert gas 是的
Cell permeable 是的
Purity ≥98% by HPLC
Solubility DMSO or MeOH
Chemical formula C18H13F3N2O3
CAS number 581797-29-7
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Standard Handling |