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658401 AG 490
α-Cyano-(3,4-dihydroxy)-N-benzylcinnamide, Tyrphostin B42, (E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide, JAK1 Inhibitor II, JAK2 Inhibitor VI, JAK3 Inhibitor VIII
A cell-permeable, reversible, substrate competitive, and potent inhibitor of epidermal growth factor receptor kinase autophosphorylation (IC50 = 100 nM). Inhibition of JAK2 by AG 490 selectively blocks leukemic cell growth in vitro and in vivo by inducing programmed cell death, with no harmful effect on normal hematopoiesis. Inhibits the constitutive activation of STAT-3 DNA binding and IL-2-induced growth of MF tumor cells. AG 490 has also been shown to inhibit the autokinase activity of JAK3. A 100 mM (5 mg/170 µl) solution of AG490 (Cat. No. 658411) in DMSO is also available.
产品信息
Form Yellow solid
Primary Target epidermal growth factor receptor kinase autophosphorylation
Primary Target IC50 100 nM
Secondary target autokinase activity of JAK3, JAK2, constitutive activation of STAT-3 DNA binding and IL-2-induced growth of MF tumor cells
Protect from Light 是的
Purity ≥98% by HPLC
Chemical formula C17H14N2O3
CAS number 133550-30-8
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Standard Handling |