|
AG 82
α-Cyano-(3,4,5-trihydroxy)cinnamonitrile, Tyrphostin A25
A cell-permeable, reversible, and competitive inhibitor of substrate binding on protein tyrosine kinases. Inhibits epidermal growth factor receptor tyrosine kinase (IC50 = 3 µM) and the GTPase activity of transducin (IC50 = 7 µM). Inhibits neuromedin B-induced phosphorylation of p125FAK (focal adhesion kinase). Blocks the induction of inducible nitric oxide synthase in glial cells. Induces apoptosis in human leukemic cell lines.
产品信息
Form Dark yellow solid
Primary Target epidermal growth factor receptor tyrosine kinase
Primary Target IC50 3 µM
Secondary target GTPase activity of transducin (IC50 = 7 µM), neuromedin B-induced phosphorylation of p125FAK (focal adhesion kinase)
Molar mass 202.2
Protect from Light 是的
Cell permeable 是的
Purity ≥98% by HPLC
Solubility DMSO or MeOH
Chemical formula C10H6N2O3
CAS number 118409-58-8
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Standard Handling |