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AG 18
α-Cyano-(3,4-dihydroxy)cinnamonitrile, Tyrphostin A23, RG-50810
A broad-spectrum protein tyrosine kinase inhibitor. Inhibits epidermal growth factor receptor autophosphorylation (IC50 = 40 µM) and the GTPase activity of transducin (IC50 = 10 µM). Inhibits aldosterone secretion in response to Angiotensin II (Cat. No. 05-23-0101). Suppresses the activation of MAP kinases by cholecystokinin in pancreatic acini.
产品信息
Form Yellow solid
Primary Target epidermal growth factor receptor autophosphorylation
Primary Target IC50 40 mM
Secondary target the GTPase activity of transducin (IC50 = 10 mM), aldosterone secretion in response to Angiotensin II
Molar mass 186.2
Protect from Light 是的
Purity ≥98% by HPLC
Solubility Acetic acid, DMSO, or EtOH
Chemical formula C10H6N2O2
CAS number 118409-57-7
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Standard Handling |