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SB 203580
4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole, p38 MAP Kinase Inhibitor XVI
Reduces epirubicin-induced cell injury and caspase-3/7 activity. A highly specific, potent, cell-permeable, selective, reversible, and ATP-competitive inhibitor of p38 MAP kinase (IC50 = 34 nM in vitro, 600 nM in cells). Does not significantly inhibit the JNK and p42 MAP kinase at 100 µM. Inhibits IL-1 and TNF-α production from LPS-stimulated human monocytes and the human monocyte cell line THP-1 (IC50 = 50-100 nM). Inhibits bone morphogenetic protein-2-induced neurite outgrowth in PC12 cells. Also inhibits platelet aggregation caused by collagen (IC50 = 0.2-1.0 µM) or the thromboxane analog U-46619 (Cat. No. 538944). A 1 mg/ml solution of SB 203580 (Cat. No. 559398) in anhydrous DMSO is also available.
其他选项
559400 SB 203580, Iodo-
559395 SB 203580, Hydrochloride
产品信息
Form Thin film
Primary Target P38MAPK
Primary Target IC50 34 nM
Secondary target THP-1 (IC50 = 500-100 nM)
Molar mass 377.4
Protect from Light 是的
Cell permeable 是的
Purity ≥98% by HPLC
Solubility DMSO
Chemical formula C21H16N3OSF
CAS number 152121-47-6
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Irritant |