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SB 202190
4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H-imidazole, FHPI, p38 MAP Kinase Inhibitor II
A potent, reversible, competitive, and cell-permeable inhibitor of p38 MAP kinase. Inhibits p38 phosphorylation of myelin basic protein (MBP) with no effect on the activity of the ERK or JNK MAP kinase subgroups. Also inhibits the kinase activity of p38β (Ki = 16 nM; IC50 = 350 nM) and p38 phosphorylation of activating transcription factor 2 (ATF-2; IC50 = 280 nM). Blocks LPS-induced TNF-α and interleukin biosynthesis. Reported to induce LDL receptor expression in Hep52 cells. A 1 mg/ml solution of SB 202190 (Cat. No. 559397) in anhydrous DMSO is also available.
其他选项
559393 SB 202190, Hydrochloride
产品信息
Form Pale yellow solid
Primary Target p38β
Primary Target IC50 16 nM
Secondary target ATF-2 (IC50 = 280 nM)
Molar mass 331.3
Protect from Light 是的
Cell permeable 是的
Purity ≥98% by HPLC
Solubility DMSO
Chemical formula C20H14FN3O
CAS number 152121-30-7
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Standard Handling |