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559389 SB 203580
4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole
Reduces epirubicin-induced cell injury and caspase-3/7 activity. A highly specific, potent, cell-permeable, selective, reversible, and ATP-competitive inhibitor of p38 MAP kinase (IC50 = 34 nM in vitro, 600 nM in cells). Does not significantly inhibit the JNK and p42 MAP kinase at 100 µM. Inhibits IL-1 and TNF-α production from LPS-stimulated human monocytes and the human monocyte cell line THP-1 (IC50 = 50-100 nM). Inhibits bone morphogenetic protein-2-induced neurite outgrowth in PC12 cells. Also inhibits platelet aggregation caused by collagen (IC50 = 0.2-1.0 µM) or the thromboxane analog U-46619 (Cat. No. 538944). A 1 mg/ml solution of SB 203580 (Cat. No. 559398) in anhydrous DMSO is also available.
Alternatives
559395 SB 203580, Hydrochloride
559400 SB 203580, Iodo-
Alternative products for SB 203580
559395 SB 203580, Hydrochloride
559400 SB 203580, Iodo-
Accessories for SB 203580
Product information
Form Thin film
Primary Target P38MAPK
Primary Target IC50 34 nM
Secondary target THP-1 (IC50 = 500-100 nM)
Molar mass 377.4
Protect from Light Yes
Cell permeable Yes
Purity ≥98% by HPLC
Solubility DMSO
Chemical formula C21H16N3OSF
CAS number 152121-47-6
Store and ship information
Storage -20°C
Ship Ambient Temperature Only
Irritant
Safety information
S Phrase S: 26-36-45
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
R Phrase R: 36/37/38
Irritating to eyes, respiratory system and skin.
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