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PDGFR Tyrosine Kinase Inhibitor III
4-(6,7-Dimethoxy-4-quinazolinyl)-N-(4-phenoxyphenyl)-1-piperazinecarboxamide
A cell-permeable piperazinyl-quinazoline carboxamide compound that acts as a potent, ATP-competitive, reversible, and selective inhibitor of PDGF receptor family of tyrosine kinases (IC50 = 0.05 µM for α-PDGFR; 0.08 µM for β-PDGFR; 0.05 µM for c-Kit; 0.23 µM for Flt3). Affects the activities of other kinases only at much higher concentrations (IC50 ≥ 30 µM for EGFR, FGFR, Src, PKA & PKC). Reported to block the PDGF-BB induced proliferation of porcine aorta smooth muscle cells (IC50 = 0.25 µM).
产品信息
Form White solid
Primary Target α-PDGFR
Primary Target IC50 0.05 µM
Secondary target IC50 = 0.05 µM for α-PDGFR; 0.08 µM for β-PDGFR; 0.05 µM for c-Kit; 0.23 µM for Flt3, block the PDGF-BB induced proliferation of porcine aorta smooth muscle cells IC50 = 0.25 µM
Molar mass 485.5
Protect from Light 是的
Packaged under inert gas 是的
Cell permeable 是的
Purity ≥97% by HPLC
Solubility DMSO
Chemical formula C27H27N5O4
CAS number 205254-94-0
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Carcinogenic / Teratogenic |