PDGFR Tyrosine Kinase Inhibitor II (5-Butanoate-1H-2-indolyl)(1H-2-indolyl)-methanone, [2-(1H-2-Indolylcarbonyl)-1H-5-indolyl]butanoate, D-65476 A cell-permeable bis(1H-2-indolyl)-1-methanone compound that acts as a highly selective, ATP-competitive and reversible inhibitor of platelet-derived growth factor (PDGF) receptor tyrosine kinase (IC50 = 1.1 µM in Swiss 3T3 cells for PDGFR). Also potently inhibits Flt3 (Fms-like tyrosine kinase 3) activity (IC50 = 6.2 µM for hPDGFβ-R-mFlt3 and 50 nM in EOL-1 cells). Sensitizes 32D cells to radiation-induced apoptosis and inhibits proliferation of TEL-Flt3-transfected BA/F3 cells (IC50 < 300 nM). May also serve as a prodrug form of the Platelet Derived Growth Factor Receptor Tyrosine Kinase Inhibitor I (Cat. No. 521230) in cells. 产品信息 Form Yellow solid Primary Target PDGFR in swiss 3T3 cells Primary Target IC50 1.1 µM Secondary target Flt3 (Fms-like tyrosine kinase 3) activity (IC50 = 6.2 µM for hPDGFb-R-mFlt3 and 50 nM in EOL-1 cells) Molar mass 346.4 Protect from Light 是的 Packaged under inert gas 是的 Cell permeable 是的 Purity ≥97% by HPLC Solubility DMSO Chemical formula C21H18N2O3 CAS number 249762-74-1 商店和运输信息 Storage +2°C to +8°C Ship Ambient Temperature Only