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PDGFR Tyrosine Kinase Inhibitor IV
3-Fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine, JNJ-10198409
A cell-permeable indenopyrazole compound that displays potent antiproliferative properties in several human tumor cell lines (IC50 < 33 nM). Shown to act as an ATP-competitive and reversible inhibitor of PDGFR (IC50 = 4.2 nM and 45 nM for -β and -α, respectively) and c-Abl (IC50 = 22 nM). Exhibits less activity towards Lck, c-Src, and Fyn (IC50 = 100 nM, 185 nM and 378 nM, respectively) and exhibits little or no inhibition toward VEGFR, HER-2, Cdk's-1,-2,-4 &-7, bFGFR-1 and EGFR (IC50 = 3.1 µM, > 10 µM, > 10 µM, 45.8 µM and > 100 µM, respectively).
产品信息
Form Off-white solid
Molar mass 325.3
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥98% by HPLC
Solubility DMSO or MeOH
Chemical formula C18H16FN3O2
CAS number 627518-40-5
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Harmful |