p38 MAP Kinase Inhibitor IX N-(Isoazol-3-yl)-4-methyl-3-(1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)benzamide A cell-permeable pyrazolo-pyrimidine compound that acts as a potent ATP-binding pocket-targeting inhibitor against p38α MAP kinase activity (IC50 = 5 nM; Ki = 0.2 nM), while exhibiting little or no activity against a panel of 21 other commonly studied kinases and 5 CYP 450 isozymes (IC50 ≥40 µM). Shown to be orally active in mice with excellent pharmacokinetics and in vivo efficacy in lowering (>70%; 5 mg/kg p.o. 5 h prior to LPS challenge) LPS-induced plasma TNFα production. 产品信息 Form Off-white solid Molar mass 411.4 Protect from Light 是的 Packaged under inert gas 是的 Purity ≥95% by HPLC Solubility DMSO Chemical formula C22H17N7O2 CAS number 630106-85-3 商店和运输信息 Storage +2°C to +8°C Ship Ambient Temperature Only Standard Handling