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p38 MAP Kinase Inhibitor VII, SD-169
Indole-5-carboxamide
A cell-permeable indole compound that acts as a potent, ATP-competitive, and isozyme-selective p38α MAP kinase inhibitor (IC50 = 3.2 nM). It inhibits p38β only at much higher concentrations (IC50 = 122 nM) and exhibits little activity against p38γ, ERK2, JNK-1, or MAPKAPK-2 even at concentrations as high as 50 µM. When administered to NOD mice via food intake in vivo, SD-169 is shown to prevent the development of type 1 diabetes in prediabetic mice and display therapeutic efficacy in treating animals already in mild and moderate hyperglycemic states.
产品信息
Form Off-white solid
Molar mass 160.2
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥97% by HPLC
Solubility DMSO or H2O
Chemical formula C9H8N2O
CAS number 1670-87-7
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Harmful |