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p38 MAP Kinase Inhibitor VIII
(4-((2-Amino-4-bromophenyl)amino)-2-chlorophenyl)-(2-methylphenyl)methanone
A cell-permeable aminobenzophenone compound that acts as a potent, ATP-binding pocket-targeting inhibitor against p38α and p38β2 (82% and 93% inhibition with 1 µM inhibitor, respectively; IC50 of p38α inhibition = 40 nM) with little activity against a panel of 57 other kinases, including p38γ, p38δ, Erk1/2, and JNK1. Shown to inhibit LPS-induced cytokine productions in human PBMC's in vitro and exhibit in vivo efficacy in both acute and chronic murine models of skin inflammation.
产品信息
Form Yellow solid
Molar mass 415.7
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥97% by HPLC
Solubility DMSO or EtOH
Chemical formula C20H16BrClN2O
CAS number 321351-00-2
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Standard Handling |