产品说明 A cell-permeable ureidocarboxamido thiophene compound that acts as a potent, reversible, and ATP-competitive inhibitor of IKK-2 (IC50 = 18 nM) with selectivity over IKK-1, JNK and p38 MAPK. Inhibits TNF-α production in human monocytes (IC50 in the range of 0.15-2.5 µM) and blocks IL-8 and IL-6 production by synovial fibroblasts (IC50 = 100 nM). Further reduces paw oedema in rat arthritis model (~100% inhibition at a dose of 30 mg per kg). A 10 mM (500 µg/179 µl) solution of IKK-2 Inhibitor IV (Cat. No. 401484) in DMSO is available. 产品信息 Form Pale yellow solid Primary Target IKK-2 Primary Target IC50 18 nM Secondary target TNF-α production in human monocytes (IC50 in the range of 0.15-2.5 µM) and blocks IL-8 and IL-6 production by synovial fibroblasts (IC50 = 100 nM) Protect from Light 是的 Packaged under inert gas 是的 Cell permeable 是的 Purity ≥95% by HPLC Chemical formula C12H10FN3O2S CAS number 507475-17-4 Storage +2°C to +8°C Ship Ambient Temperature Only Standard Handling