产品说明 A cell-permeable quinoxaline compound that displays anti-inflammatory properties. Acts as a potent, selective, and allosteric site-binding inhibitor of IKK-2 (IC50 = ~ 300 nM). Exhibits ~10-fold greater selectivity over IKK-1 (IC50 = ~ 4 µM) and no activity towards IKKε and a panel of more than 15 unrelated protein kinases even at concentrations as high as 100 µM. Inhibits cellular IκBα phosphorylation (IC50 = 4 µM in THP-1 cells) and LPS-induced cytokine production both in vitro (IC50 = 1-5 µM in THP-1 cells) and in vivo (IC50 = 10 mg/kg in mice). Effectively blocks inflammation and joint destruction in a murine arthritis model. 产品信息 Form Off-white solid Formulation Supplied as bis-TFA salt. Primary Target IKK-2 Primary Target IC50 300 nM Secondary target IKK-1 (IC50 ~ 4 µM) Protect from Light 是的 Hygrocopic 是的 Packaged under inert gas 是的 Cell permeable 是的 Purity ≥96% by HPLC Chemical formula C14H17N5•2CF3CO2H CAS number 445430-58-0 Storage +2°C to +8°C Ship Ambient Temperature Only Standard Handling