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产品说明
A cell-permeable (thienothienyl)amino-acetamide compound that displays anti-inflammatory properties. Acts as a potent, reversible, ATP-competitive, and highly selective inhibitor of IKK-2 (IC50 = ~ 3-12 µM for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2). Its specificity has been confirmed using a panel of 31 other kinases, including IKK isoforms IKK-1, IKK-i, and TBK-1 (IC50 > 200 µM). Shown to specifically block NF-κB-dependent gene expression, but not MAP kinase pathways, in stimulated synovial fibroblasts RASF. A 25 mM (1 mg/178 µl) solution of IKK-2 Inhibitor, SC-514 (Cat. No. 401485) in DMSO is also available.
产品信息
Form Pale yellow solid
Primary Target IKK-2
Primary Target IC50 3-12 µM
Secondary target TBK-1 (IC50 > 200 µM)
Protect from Light 是的
Packaged under inert gas 是的
Cell permeable 是的
Reversible 是的
ATP Competitive 是的
Purity ≥95% by HPLC
Chemical formula C9H8N2OS2
CAS number 354812-17-2
Storage +2°C to +8°C
Ship Ambient Temperature Only
Carcinogenic / Teratogenic |