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Casein Kinase II Inhibitor IX, IQA
5-Oxo-5,6-dihydroindolo[1,2-a]quinazoline-7-acetic acid
A cell-permeable indoloquinazolinone compound that acts as a potent and selective CK2 inhibitor (IC50 = 390 nM with 100 µM ATP) in an ATP- and GTP-competitive manner (Ki = 0.17 and 0.21 µM, respectively). IQA exhibits much reduced activity against PI 3-Kα/β/γ (No inhibition at 20 µM) and 48 commonly studied protein kinases (IC50 ≥10 µM with 100 µM ATP) and is more selective than TBB (Cat. Nos. 218697 and 218708) with respect to DYRK1a (IC50 = 8 and <1 µM, respectively, with 100 µM ATP).
产品信息
Form Light yellow solid
Molar mass 292.3
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥95% by HPLC
Solubility DMSO
Chemical formula C17H12N2O3
CAS number 391670-48-7
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Standard Handling
安全标示
S Phrase S: 22-24/25
Do not breathe dust.
Avoid contact with skin and eyes. |