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Anti-p67-phox Antibody
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REFERENCES
Localization of a constitutively active, phagocyte-like NADPH oxidase in rabbit aortic adventitia: enhancement by angiotensin II.
Pagano, P J, et al. (1997) Proc. Natl. Acad. Sci. U.S.A., 94: 14483-8 (1997)
Cloning and sequencing of rabbit leukocyte NADPH oxidase genes reveals a unique p67(phox) homolog
Gauss, K. A., et al (2002) J Leukoc Biol, 71:319-28 (2002)
Molecular characterization of a superoxide-generating NAD(P)H oxidase in the ventilatory muscles
Javesghani, D., et al (2002) Am J Respir Crit Care Med, 165:412-8 (2002)
Species Reactivity Key Applications Host Format Antibody Type
H IP, WB, ICC Rabbit Serum Polyclonal Antibody
Description:
Anti-p67-phox Antibody
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Trade Name:
Upstate (Millipore)
Specificity:
p67-phox
Molecular Weight:
65kDa
Immunogen:
GST fusion protein corresponding to full-length human p67-phox.
Isotype:
IgG
Species Reactivity:
Human
Quality Assurance:
routinely evaluated by immunoblot on RIPA lysates from HL-60 cells
Purification Method:
Antiserum
Presentation:
rabbit antiserum containing 0.05% azide
Storage Conditions:
2 years at -20°C
UniProt Number:
P19878
Entrez Gene Number:
NM_000433
Gene Symbol:
NCF2
NCF-2
NOXA2
p67phox
p67-phox
P67-PHOX
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Immunoprecipitation
Western Blotting
Immunocytochemistry
Entrez Gene Summary:
This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein complex known as NADPH oxidase found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease.
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UniProt Summary:
FUNCTION: SwissProt: P19878 # NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).
SIZE: 526 amino acids; 59762 Da
SUBUNIT: Interacts with SYTL1 and RAC1. May interact with NOXO1.
SUBCELLULAR LOCATION: Cytoplasm.
DISEASE: SwissProt: P19878 # Defects in NCF2 are a cause of autosomal recessive chronic granulomatous disease (AR-CGD) [MIM:233710]; also known as autosomal cytochrome-b-positive chronic granulomatous disease. It causes recurrent infection by catalase-positive organisms.
SIMILARITY: SwissProt: P19878 ## Contains 1 OPR domain. & Contains 2 SH3 domains. & Contains 3 TPR repeats.
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Brand Family:
Upstate
Product Name:
Anti-p67-phox Antibody
Antibody Type:
Polyclonal Antibody
Qty/Pk:
200 µL
Format:
Serum
Host:
Rabbit
Applications:
This Anti-p67-phox Antibody is validated for use in IP, WB, IC for the detection of p67-phox. |