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Anti-p47-phox Antibody
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REFERENCES
Antrocamphin A, an anti-inflammatory principal from the fruiting body of Taiwanofungus camphoratus , and its mechanisms.
Hsieh YH, Chu FH, Wang YS, Chien SC, Chang ST, Shaw JF, Chen CY, Hsiao WW, Kuo YH, Wang SY (2010) J Agric Food Chem.58:3153-8.
Molecular diagnosis of X-linked chronic granulomatous disease in Iran.
S Teimourian, Z Rezvani, M Badalzadeh, C Kannengiesser, D Mansouri, M Movahedi, E Zomorodian, N Parvaneh, S Mamishi, Z Pourpak, M Moin, S Teimourian, Z Rezvani, M Badalzadeh, C Kannengiesser, D Mansouri, M Movahedi, E Zomorodian, N Parvaneh, S Mamishi, Z Pourpak, M Moin (2008) International journal of hematology.87:398-404
Molecular characterization of a superoxide-generating NAD(P)H oxidase in the ventilatory muscles
Javesghani, D., et al (2002) Am J Respir Crit Care Med, 165:412-8 (2002)
Localization of a constitutively active, phagocyte-like NADPH oxidase in rabbit aortic adventitia: enhancement by angiotensin II
Pagano, P J, et al (1997) Proc Natl Acad Sci USA, 94:14483-8 (1997)
Species Reactivity Key Applications Host Format Antibody Type
H ICC, IP, WB Rabbit Serum Polyclonal Antibody
Description:
Anti-p47-phox Antibody
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Trade Name:
Upstate (Millipore)
Specificity:
Recognizes p47 phox.
Molecular Weight:
47 kDa
Immunogen:
GST fusion protein corresponding to full-length human p47-phox
Isotype:
IgG
Species Reactivity:
Human
Control:
HL-60 cell lysate
Quality Assurance:
routinely evaluated by immunoblot on RIPA lysates from HL-60 cells
Purification Method:
Unpurified
Presentation:
Immunoaffinity Purified immunoglobulin in 0.2M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide, 5mg/ml BSA before the addition of glycerol to 30%
Storage Conditions:
Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
UniProt Number:
P14598
Entrez Gene Number:
NM_000265
Gene Symbol:
NCF1
NCF-47K
NOXO2
p47-phox
SH3PXD1A
NCF1A
p47phox
NCF-1
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Immunocytochemistry
Immunoprecipitation
Western Blotting
Entrez Gene Summary:
The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with chronic granulomatous disease.
UniProt Summary:
FUNCTION: SwissProt: P14598 # NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).
SIZE: 390 amino acids; 44683 Da
SUBCELLULAR LOCATION: Cytoplasm.
DISEASE:SwissProt: P14598 # Defects in NCF1 are the cause of autosomal cytochrome-b- positive chronic granulomatous disease type 1 (CGD) [MIM:233700]; an autosomal recessive form.
SIMILARITY: SwissProt: P14598 ## Contains 1 PX (phox homology) domain. & Contains 2 SH3 domains.
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