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Anti-CAP (c-Cbl associated protein) Antibody
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REFERENCES
A role for CAP, a novel, multifunctional Src homology 3 domain-containing protein in formation of actin stress fibers and focal adhesions.
Ribon, V, et al. (1998) J. Biol. Chem., 273: 4073-80 (1998)
A novel, multifuntional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes.
Ribon, V, et al. (1998) Mol. Cell. Biol., 18: 872-9 (1998)
Species Reactivity Key Applications Host Format Antibody Type
H, M WB Rabbit Purified Polyclonal Antibody
Description:
Anti-CAP (c-Cbl associated protein) Antibody
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Trade Name:
Upstate (Millipore)
Specificity:
CAP and two other isoforms or alternatively spliced variants at 125 and 53kDa; other splice variants that may be detected are at 75kDa and 45kDa
Molecular Weight:
99kDa
Immunogen:
KLH-conjugated, synthetic peptide corresponding to amino acids 192-206 (CEKRAKDDSRRVVKST) of human CAP (c-Cbl associated protein), also known as ponsin
Isotype:
IgG
Species Reactivity:
Human
Mouse
Quality Assurance:
routinely evaluated by immunoblot on a RIPA lysate prepared from a 3T3-L1 adipocytes
Purification Method:
Protein A chromatography
Presentation:
0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Storage Conditions:
2 years at -20°C
UniProt Number:
Q9BX66
Entrez Gene Number:
NM_015385
Gene Symbol:
SORBS1
SH3P12
DKFZp586P1422
DKFZP586P1422
DKFZp451C066
KIAA1296
Ponsin
SH3D5
FLAF2
sh3p12
SORB1
ponsin
R85FL
FLJ12406
CAP
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
UniProt Summary:
FUNCTION: SwissProt: Q9BX66 # Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin- stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity).
SIZE: 1292 amino acids; 142455 Da
SUBUNIT: Interacts with the long isoform of MLLT4/afadin and with VCL. MLLT4 and VCL bind to SORBS1 in a competitive manner and do not form a ternary complex. Interacts with ABL1, CBL, CBLB and INPPL1/SHIP2 through the third SH3 domain. Interaction with ABL1 occurs only after insulin stimulation while this has no effect on the interaction with INPPL1. Interacts with the insulin receptor but dissociates from it following insulin stimulation. Also interacts with SCA7, PTK2/p125FAK and flotillin.
SUBCELLULAR LOCATION: Cell junction, adherens junction. Cell membrane. Cytoplasm, cytoskeleton. Note=Colocalizes with actin stress fibers. Also detected at the plasma membrane and in neuronal intranuclear inclusions.TISSUE SPECIFICITY: Widely expressed with highest levels in heart and skeletal muscle.
PTM: O-glycosylated (By similarity).
SIMILARITY: SwissProt: Q9BX66 ## Contains 3 SH3 domains. & Contains 1 SoHo domain.
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Brand Family:
Upstate
Product Name:
Anti-CAP (c-Cbl associated protein) Antibody
Antibody Type:
Polyclonal Antibody
Qty/Pk:
200 |