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Functional Aspects:
Choline Acetyltransferase (ChAT) is an enzyme that catalyzes the synthesis of acetylcholine from choline and acetyl coenzyme A, and is found in cholinergic neurons in the CNS. Interestingly, specific loss of cholinergic neurons has been reported in the basal forebrain in Lewy Body Dementia and Alzheimer’s disease. It does not react with axons in the insular cortex or the internal capsule, non-cholinergic structures, endothelial cells or microglia. |