Functional Aspects:Checkpoint Kinase 1 is a protein that in its phosphorylated form regulates cell cycle progression in response to agents that block DNA replications. Eukaryotic cells exposed to ionizing radiation or other genotoxic stresses activate checkpoints to delay cell cycle progression. Cell cycle kinases act upstream of p53 in DNA damage response and mutations of these kinases are implicated in certain cancer development. This antibody will help detect checkpoint kinase 1 and further characterize its expression in a variety of tissues.
