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Schizophyllan
Beta-glucan from Schizophyllum commune - β(1➝3, 1➝6)-glucan
Schizophyllan (SPG) is a gel-forming β-glucan from the fungus Schizophyllum commune.
SPG is a high molecular weight (450 kDa) (1-3)-β-D-glucan that has a 1,6-β-monoglucosyl branch in every three 1,3-β-glucosyl residues on the main chain.
SPG binds to Dectin-1 [1] and triggers a signaling cascade leading to NF-κB activation. Detection of β-glucans by Dectin-1 receptor leads to the CARD9-dependent activation of NF-κB and MAP kinases [2].
Specificity: Dectin-1 ligand
CAS number: 9050-67-3
Synonym: SPG
Partial structure: β(1➝3, 1➝6)-glucan
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