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Lichenan
Beta-glucan from Cetriana islandica - β(1➝3, 1➝4)-glucan
Lichenan (or lichenin) is a median molecular weight (22 kDa), linear glucan of (1-3, 1-4)-β-glycosidic bonds that originates from the lichen Cetraria islandica.
The proportion of 1-4 to 1-3 linkage is approximately 2:1. Lichenan binds to Dectin-1 [1] and initiates downstream signaling leading to NF-κB activation. Detection of β-glucans by Dectin-1 receptor leads to the CARD9-dependent activation of NF-kB and MAP kinases [2].
Specificity: Dectin-1 ligand
CAS number: 1402-10-4
Partial structure: β(1➝3, 1➝4)-glucan
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