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Laminarin
Soluble beta-glucan from Laminaria digitata - β(1➝3, 1➝6)-glucan
Laminarin from the brown seaweed Laminaria digitata is a linear β(1-3)-glucan with β(1-6)-linkages.
Laminarin is a low molecular weight (6 kDa), water-soluble β-glucan. It can bind to Dectin-1 without stimulating downstream signaling [1] and is able to block binding to Dectin-1 of particulate β(1-3)-glucans, such as zymosan [2-3].
The activity of laminarin on Dectin-1 seems to vary depending on the isoform. Cells expressing the human dectin-1b isoform do not respond to Laminarin, whereas cells expressing the human dectin-1a isoform are highly responsive to Laminarin [4].
Specificity: Dectin-1 ligand
CAS Number: 9008-22-4
Solubility: water 20 mg/ml
Partial structure: β(1➝3, 1➝4)-glucan
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