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RIZ1 (2-200 aa) (GST-tagged), Human recombinant
A SAM-dependent histone methyltransferase
Product Overview
Product Name: RIZ1 (2-200 aa) (GST-tagged), Human recombinant
Alternate Name/Synonyms: KMT8; PRDM2; PR Domain Zinc Finger Protein 2; Retinoblastoma Protein-interacting Zinc Finger Protein
Gene Symbol: PRDM2
Accession #: Q13029
Gene ID: 7799
Source: E. coli
Appearance: Liquid
Physical Form Description: 50 mM Tris, pH 7.5, containing 150 mM sodium chloride and 20% glycerol.
Molecular Weight: 49.5 kDa (2-200 aa + NT GST Tag)
Purity by SDS-PAGE: ≥95%
Purity by HPLC: N/A
Endotoxin Level: N/A
Biological Activity: N/A.
Reconstitution Instructions: N/A
Storage Temp.: -80°C
Shipping: Dry ice
Background Information: Retinoblastoma protein-interacting zinc finger protein 1 (RIZ1), also known as PRDM2, is a SAM-dependent histone methyltransferase that specifically methylates histone H3 on lysine 9. RIZ1 contains 8 zinc-finger motifs and 1 PR domain. The RIZ gene encodes two different proteins, RIZ1 and RIZ2. RIZ1 is a tumor suppressor that can arrest the cell cycle and induce apoptosis. RIZ2 however, is a proto-oncoprotein lacking the N-terminal PR domain containing the methyltransferase activity. When RIZ1 is silenced or mutated, the reduced methyltransferase activity can lead to inheritable changes in chromatin methylation and gene expression patterns.
Amino Acid Sequence: N/A
Handling: Centrifuge the vial prior to opening
USAGE: For Research Use Only! Not For Use in Humans. |