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Polybromo-1D bromodomain 1 (23-156 aa) (GST-tagged), Human recombinant
A bromodomain invloved in cell cycle regulation and tumor suppression
Product Overview
Product Name: Polybromo-1D bromodomain 1 (23-156 aa) (GST-tagged), Human recombinant
Alternate Name/Synonyms: MGC165155; PBRM1; MGC165156; BAF180; Protein Polybromo-1; BRG1-associated factor 180; hPB1; PB1
Gene Symbol: PBRM1
Accession #: Q86U86
Gene ID: 55193
Source: E. coli
Appearance: Liquid
Physical Form Description: 50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5% glycerol, and 5 mM β-mercaptoethanol.
Molecular Weight: 42.8 kDa (23-156 aa + NT GST Tag)
Purity by SDS-PAGE: ≥95%
Purity by HPLC: N/A
Endotoxin Level: N/A
Biological Activity: N/A.
Reconstitution Instructions: N/A
Storage Temp.: -80°C
Shipping: Dry ice
Background Information: The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. The PBRM1 gene encodes the bromodomain-containing protein Polybromo-1D (PBRM1). PBRM1 contains six bromodomains and is a component of the SWI/SNF complex, PBAF. PBAF is targeted to acetylated sites in chromatin by the PBRM1 bromodomains, where it plays a role in cell cycle regulation and tumor suppression. This product contains the bromodomain 1 region of PBRM1.
Amino Acid Sequence: N/A
Handling: Centrifuge the vial prior to opening
USAGE: For Research Use Only! Not For Use in Humans. |