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BRM bromodomain (1367-1511 aa) (GST-tagged), Human recombinant
A protein involved in transcriptional activation of genes normally repressed by chromatin.
Product Overview
Product Name: BRM bromodomain (1367-1511 aa) (GST-tagged), Human recombinant
Alternate Name/Synonyms: SMARCA2A/B; SWI/SNF ATPase
Gene Symbol: SMARCA2
Accession #: P51531
Gene ID: 6595
Source: E. coli
Appearance: Liquid
Physical Form Description: 50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5% glycerol, and 5 mM β-mercaptoethanol.
Molecular Weight: 43.7 kDa (1367-1511 aa + NT GST Tag)
Purity by SDS-PAGE: ≥95%
Purity by HPLC: N/A
Endotoxin Level: N/A
Biological Activity: N/A
Reconstitution Instructions: N/A
Storage Temp.: -80°C
Shipping: Dry ice
Background Information: The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. BRM is a member of the SWI/SNF protein family, which forms part of a large ATP-dependent chromatin remodeling complex. This complex is required for transcriptional activation of genes normally repressed by chromatin.
Amino Acid Sequence: N/A
Handling: Centrifuge the vial prior to opening
USAGE: For Research Use Only! Not For Use in Humans. |