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Leptomycin B
Description
Leptomycin B (LepB) is an antifungal antibiotic, found to be a potent antitumor agent. It is suggested that the antitumor effect is related to cytochrome c release, activation of caspases, and selective down-regulation ofMc1-1 and XIAP. Leptomycin B has
Specifications
Cas No. 87081-35-4
Product ID L1761
Product Name Leptomycin B
Chemical Name 19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo- 2,10,12,16,18-Nonadecapentaenoic acid
Synonym LMB; Elactocin, CI-940, CL-1957A, NSC-364372, PD-114720.
Formula Wt. 540.74
Melting Point 41oC-44oC
Purity ≥98%
Solubility Soluble in ethanol or methanol.
Stability WARNING: Small quantities of LepB are reported to be unstable when dried down into a film. Thus, under no circumstances should the solvent be removed from solutions of LepB, because rapid decomposition may result.
Store Temp -20oC
References Sasaki H, Yoshida M, Beppu T. Radiat Res. 129:163-70 (1992). Jang BC, Paik JH, Jeong HY et al. Biochem Pharmacol. 68:263-74 (2004). Meissner T, Krause E, Vinkemeier U. FEBS Lett. 576:27-30 (2004).Fukuda.M., et al Nature 390:308-311 (1997). Kudo, N.
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