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Human Recombinant Cyclophilin H
An immunophilin family protein catalyzing the isomerization of peptide bonds
Product Overview
Product Name: Human Recombinant Cyclophilin H
Alternate Name/Synonyms: Peptidylprolyl isomerase H, CYPH, CYP20, SnuCyp-20, PPIase H, Rotamase H
Gene Symbol: PPIH
Accession #: O43447
Gene ID: 10465
Source: E. coli
Appearance: Liquid
Physical Form Description: 1 mg/ml solution in PBS (pH 7.4) containing 10% glycerol.
Molecular Weight: 19.2 kDa
Purity by SDS-PAGE: ≥95%
Purity by HPLC: N/A
Endotoxin Level: < 1.0 EU per 1 μg of protein (determined by LAL method)
Biological Activity: Specific activity is > 220 nmoles/min/mg
Reconstitution Instructions: N/A
Storage Temp.: -80°C
Shipping: Gel pack
Background Information: Cyclophilin H is a member of peptidyl-propyl cis-trans isomerase (PPIase) family, which catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerates the folding of proteins. The cyclophilin H is a specific component of the human U4/U6 small nuclear ribonucleoprotein particle involved in the nuclear splicing of pre-mRNA. It stably associates with the U4/U6-60kD and -90kD proteins, the human orthologues of the Saccharomyces cerevisiae Prp4 and Prp3 splicing factors.
Amino Acid Sequence: MAVANSSPVN PVVFFDVSIG GQEVGRMKIE LFADVVPKTA ENFRQFCTGE FRKDGVPIGY KGSTFHRVIK DFMIQGGDFV NGDGTGVASI YRGPFADENF KLRHSAPGLL SMANSGPSTN GCQFFITCSK CDWLDGKHVV FGKIIDGLLV MRKIENVPTG PNNKPKLPVV ISQCGEM
Handling: Centrifuge the vial prior to opening
USAGE: For Research Use Only! Not For Use in Humans. |